CONCOMITANT USE OF STRONG CYP3A INHIBITORS E.G., RITONAVIR, INDINAVIR, NELFINAVIR, SAQUINAVIR, BOCEPREVIR, TELAPREVIR, NEFAZODONE IS NOT RECOMMENDED. REDUCE IBRUTTINIB DOSE TO 140 MG IF A MODERATE CYP3A INHIBITOR MUST BE USED (E.G., FLUCONAZOLE, DARUNAVIR, ERYTHROMYCIN, DILTIAZEM, ATAZANAVIR, APREPITANT, AMPRENAVIR, FOSAMPREVIR, CRIZOTINIB, IMATINIB, VERAPAMIL, AND CIPROFLOXACIN.