IN COMBINATION WITH CHLORAMBUCIL, IT IS INDICATED FOR THE TREATMENT OF PATIENTS WITH PREVIOUSLY UNTREATED CHRONIC LYMPHOCYTIC LEUKEMIA.
EACH DOSE IS 1000 MG, ADMINISTERED INTRAVENOUSLY, WITH THE EXCEPTION OF THE FIRST INFUSIONS IN CYCLE 1, WHICH ARE ADMINISTERED ON DAY 1 (100 MG) AND DAY 2 (900 MG).
DOSE TO BE ADMINISTERED DURING 6 TREATMENT CYCLES EACH OF 28 DAYS DURATION:
DAY OF TT CYCLE DOSE/RATE OF INFUSION
CYCLE 1 DAY 1 100 MG AT 25 MG/HR OVER 4 HOURS
DAY 2 900 MG ADMINISTER AT 50 MG/HR
DAY 8 1000 MG AT RATE OF 100 MG/HR
DAY 15 1000 MG
INFUSIONS CAN BE STARTED AT A RATE OF 100 MG/HR AND INCREASED BY 100 MG/HR INCREMENTS EVERY 30 MINUTES TO A MAXIMUM OF 400 MG/HR
CYCLES 2-6 DAY 1 1000 MG
FOR DOSE MODIFICATION DUE TO INFUSION REACTION OR TOXICITY SEE MONOGRAPH.
PREMEDICATION IS REQUIRED TO CHECK SECONDARY BACTERIAL, VIRAL OR FUNGAL INFECTION & HYPOTENSION.