AT LEAST 14 DAYS SHOULD ELAPSE BETWEEN DISCONTINUATION OF AN MAOI INTENDED TO TREAT PSYCHIATRIC DISORDERS AND INITIATION OF THERAPY WITH LEVOMILNACIPRAN. CONVERSELY, AT LEAST 7 DAYS SHOULD BE ALLOWED AFTER STOPPING LEVOMILNACIPRAN BEFORE STARTING AN MAOI ANTIDEPRESSANT.
USE OF LEVOMILNACIPRAN WITH OTHER MAOIS SUCH AS LINEZOLID OR METHYLENE BLUE
DO NOT START LEVOMILNACIPRAN IN A PATIENT WHO IS BEING TREATED WITH LINEZOLID OR INTRAVENOUS METHYLENE BLUE BECAUSE THERE IS AN INCREASED RISK OF SEROTONIN SYNDROME.
DOSE OF LEVOMILNACIPRAN SHOULD NOT EXCEED 80 MG ONCE DAILY WHEN USED WITH STRONG CYP3A4 INHIBITORS (E.G. KETOCONAZOLE, CLARITHROMYCIN, RITONAVIR).