USED IN SYMPTOMATIC ORTHOSTATIC HYPOTENSION (NOH) CAUSED BY PRIMARY AUTONOMIC FAILURE [PARKINSON'S DISEASE (PD), MULTIPLE SYSTEM ATROPHY AND PURE AUTONOMIC FAILURE], DOPAMINE BETA-HYDROXYLASE DEFICIENCY, AND NON-DIABETIC AUTONOMIC NEUROPATHY.
RECOMMENDED STARTING DOSE IS 100 MG, THREE TIMES DAILY: UPON ARISING IN THE MORNING, AT MIDDAY, AND IN THE LATE AFTERNOON AT LEAST 3 HOURS PRIOR TO BEDTIME (TO REDUCE THE POTENTIAL FOR SUPINE HYPERTENSION DURING SLEEP). TITRATE TO SYMPTOMATIC RESPONSE, IN INCREMENTS OF 100 MG THREE TIMES DAILY EVERY 24-48 HOURS UP TO A MAXIMUM DOSE OF 600 MG THREE TIMES DAILY.
MONITOR SUPINE BLOOD PRESSURE PRIOR TO INITIATING NORTHERA AND AFTER INCREASING THE DOSE.
PATIENTS WHO MISS A DOSE SHOULD TAKE THEIR NEXT SCHEDULED DOSE.